LXQ-217
LXQ-217 is an oral active SHP2 inhibitor with the IC50 of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro.
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- CAS No.: 2524718-79-2
- 화학식: C24H20Br2N2O5
- 분자량:576.23
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
LXQ-217 (72 h) inhibits cell growth of A549, HCT116, HepG2 and MDA-MB-231 cells with the IC50 values of 2.06, 3.88, 4.53, and 5.13 μM[1].
LXQ-217 (2.5, 5, 10 μM, 7 days) decreases the clonogenic number and formation rate of A549 cells[1].
LXQ-217 (1.25, 2.5 μM, 24 h) inhibits the migration of A549 cells[1].
LXQ-217 (2.5, 5, 10 μM, 3 h) increases in the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:1.25 and2.5 μM
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Incubation Time:72 h
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Result:Inhibited the migration of A549 cells.
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Cell Line:A549 cells
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Concentration:2.5, 5 and 10 μM
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Incubation Time:3 h
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Result:Increased the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A549 cell xenograft model constructed based on BALB/c-nude mice[1]
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Dosage:50 or 100mg/kg
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Administration:Oral administration for 14 days
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Result:Lowered tumor weight and volume of mice.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Protocol for Cell Counting and Cell Density Analysis
- Somatic Cell Culture
- Apoptosis Solutions
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- MTT Cell Proliferation Assay
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS No. 2524718-79-2
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분자량 576.23
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화학식 C24H20Br2N2O5
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SMILES
CCOC(C=C1)=CC=C1OC2=CC=C(C3=NN(C=O)C(C4=C(Br)C(Br)=C(O)C(O)=C4)C3)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LXQ-217 Related Classifications
HY-161360 Related Classifications
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