m7GpppGpG
m7GpppGpG is an unmodified trinucleotide cap analog with enhancer activity. When incorporated into mRNA, it effectively enhances translational efficiency, stability, and protein expression levels of the mRNA. m7GpppGpG can serve as a standard cap analog for in vitro mRNA synthesis to support antigen generation and presentation by dendritic cells, although its expression efficiency in dendritic cells is 20-fold lower than that of the m7GpppApG cap.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 133608-76-1
- 화학식: C31H41N15O25P4
- 분자량:1147.64
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
m7GpppGpG (10 mM; 2 total hours at 37°C) generates the functional m7GpppGpG cap structure alongside non-functional reversed-capped molecules during in vitro mRNA synthesis, with overall capping efficiency of ~90% under typical conditions[1].
mRNA capped with m7GpppGpG exhibits 20-fold lower translation efficiency in JAWSII murine dendritic cells relative to mRNA capped with m7GpppApG, independent of eIF4E affinity and decapping enzyme resistance[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 133608-76-1
-
분자량 1147.64
-
화학식 C31H41N15O25P4
-
SMILES
O=P(O)(OC[C@@H]1[C@@H](OP(O)(OC[C@H]2O[C@@H](N3C(NC(N)=NC4=O)=C4N=C3)[C@H](O)[C@@H]2O)=O)[C@@H](O)[C@H](N5C(NC(N)=NC6=O)=C6N=C5)O1)OP(OP(OC[C@H]7O[C@@H](N8C(NC(N)=N9)=C([N+](C)=C8)C9=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Grudzien-Nogalska E, et al. Synthetic mRNAs with superior translation and stability properties. Methods in molecular biology (Clifton, N.J.). 2013;969:55-72. [Content Brief]
[2]. Uchida S, et al. Nanomedicine-Based Approaches for mRNA Delivery. Molecular pharmaceutics. 2020 Oct 05;17(10):3654-3684. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
m7GpppGpG Related Classifications
HY-145976 Related Classifications
Powered by Bioz