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Cat. No.: HY-155149

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MAT2A-IN-12

MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC₅₀ of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC₅₀=5 μM) in the the proliferation assay (MTAP^-/- cell line).

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CAS No.: 631897-75-1
화학식: C₂₀H₁₇NO₃
분자량:319.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MAT2A-IN-12 Chemical Structure

CAS No.: 631897-75-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4.957 μM Compound: 17; STL235627	Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]
HCT-116	IC₅₀	9.23 μM Compound: 17; STL235627	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]

Chemical Information

CAS No. 631897-75-1
분자량 319.35
화학식 C₂₀H₁₇NO₃
SMILES

CC1=CC(OC2=C3C=C(OC)C=C2)=C3C(C4=CC=C(C)C=C4)=[N+]1[O-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tuomo Kalliokoski, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett . 2023 Oct 1;94:129450 [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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