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Cat. No.: HY-115888

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MIF2-IN-1

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC₅₀ of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.

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CAS No.: 2917525-79-0
화학식: C₂₆H₁₉F₃N₂O₂S
분자량:480.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MIF2-IN-1 Chemical Structure

CAS No.: 2917525-79-0

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 1.0 μM (MIF2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3 μM Compound: 5d	Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
HCC827	IC₅₀	5.2 μM Compound: 5d	Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
NCI-H1299	IC₅₀	7.6 μM Compound: 5d	Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
NCI-H1650	IC₅₀	5.3 μM Compound: 5d	Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]

Chemical Information

CAS No. 2917525-79-0
분자량 480.50
화학식 C₂₆H₁₉F₃N₂O₂S
SMILES

O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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