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Cat. No.: HY-122249

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MT-7

MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 946507-08-0
화학식: C₂₂H₁₇N₃O₂
분자량:355.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

MT-7 Chemical Structure

CAS No.: 946507-08-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1.8 μM Compound: 1a (MT-7)	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 24360827]

In Vitro

MT-7 (0-8µM; 72 h) inhibits cell proliferation with IC₅₀ values ranging from 0.85 μM to 5.01 μM for HeLa, HL60, A549,MDA-MB-468, Lovo, HCT116, SMMC-7721, HO-8910, A375 and SG7901 cells^[1].
MT-7 (5 μM; 12 h) induces cell cycle arrest at the G2/M phase^[1].
MT-7 (5 μM; 1.5, 3, 6, 12 h) increases the gene expression of THBS, IL6 and PHLDA1, dereases the gene expression of COX5B, RPS11 and CYP26A1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HeLa cells
Concentration:

5 μM
Incubation Time:

12 h
Result:

Induced cell cycle arrest at G2/M phase and decreased the protein expression of MPM-2, Pi-H3.

RT-PCR^[1]

Cell Line:

HeLa cells
Concentration:

5 μM
Incubation Time:

1.5, 3, 6, 12 h
Result:

Upregulated the gene expression of THBS, IL6 and PHLDA1, doen-regulated the gene expression of COX5B, RPS11 and CYP26A1.

Chemical Information

CAS No. 946507-08-0
분자량 355.39
화학식 C₂₂H₁₇N₃O₂
SMILES

O=C1N(C2=C(C3=C1C=CC=C3)N=C4N2C=CC=C4)CC5=CC=C(C=C5)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Z, et al. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs. 2010 Dec;28(6):715-28. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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