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Cat. No.: HY-182643

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NO-794

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers.

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CAS No.: 105150-87-6
화학식: C₂₃H₂₈N₄O₂
분자량:392.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NO-794 Chemical Structure

CAS No.: 105150-87-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

NO-794 is a histamine H₂ receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers^[1].

IC₅₀ & Target^[1]

H₂ Receptor

All Histamine Receptor Isoforms :

In Vitro

NO-794 (0-30 min) is a potent, time-dependent and irreversible histamine H₂ receptor antagonist acting on dispersed guinea pig gastric mucosal cells, with a -log K_B value of 8.4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NO-794 (0.5-2 mg/kg; intradermal injection; single administration) potently inhibits gastric acid secretion in pylorus-ligated rats, with an ED₅₀ of 0.9 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 180-210 g, pylorus-ligated model)^[1]
Dosage:

0.5 mg/kg; 1.0 mg/kg; 2 mg/kg
Administration:

i.d.; single dose
Result:

Reduced gastric acid output compared to controls at 0.5 mg/kg.
Significantly reduced gastric acid output by greater margins at 1.0 mg/kg and 2.0 mg/kg.
Achieved an ED50 value of 0.9 mg/kg for reduction of gastric acid secretion.
Demonstrated approximately 14 times more potency than ranitidine.

Chemical Information

CAS No. 105150-87-6
분자량 392.49
화학식 C₂₃H₂₈N₄O₂
SMILES

O=C1NC(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=C1C=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Oshita M, et al. Pharmacological studies of 2-(3-(3-(1-piperidinylmethyl)-phenoxy)propylamino)-4 (3H)-quinazolinone (NO-794), a new histamine H2-receptor antagonist. Jpn J Pharmacol. 1986 Oct;42(2):229-35. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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NO-794

All Histamine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NO-794 Related Classifications

HY-182643 Related Classifications