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Cat. No.: HY-181853

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NOTA-SP2A-PSMAL

NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC₅₀ value of 0.26 nM. ¹⁸F-labeled NOTA-SP₂A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP₂A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs).

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화학식: C₅₅H₇₉N₁₁O₂₅S₂
분자량:1358.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-SP2A-PSMAL Chemical Structure

Amount: USD 0.00

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

NOTA-SP₂A-PSMAL exhibits a binding energy of -10.2 K_cal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability^[1].
NOTA-SP₂A-PSMAL (10^-12 to 10^-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC₅₀ = 0.26 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 1358.40
화학식 C₅₅H₇₉N₁₁O₂₅S₂
SMILES

OC(CC[C@H](C(O)=O)NC(NC(C(O)=O)CCCCNC(C(CC1=CC=C(C=CC=C2)C2=C1)NC([C@H]3CC[C@@H](CNC([C@@H](CC(O)=O)NC([C@H](CS(=O)(O)=O)NC([C@@H](CS(=O)(O)=O)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)=O)=O)CC3)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Design, Synthesis, and Preclinical Evaluation of a Novel [¹⁸F]AlF-Labeling Positron Emission Tomography Tracer Targeting Prostate-Specific Membrane Antigen. J Med Chem. 2026;69(4):4888-4899. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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NOTA-SP2A-PSMAL

All Radionuclide-Drug Conjugates (RDCs) Isoforms