PAD4-IN-3
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment.
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- CAS No.: 2642327-44-2
- 화학식: C21H26BClN4O4
- 분자량:444.72
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
PAD4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
>100 μM
Compound: 5a
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 37421890] |
Chemical Information
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CAS No. 2642327-44-2
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분자량 444.72
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화학식 C21H26BClN4O4
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SMILES
O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAD4-IN-3 Related Classifications
HY-157157 Related Classifications
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