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Cat. No.: HY-150723

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PBI-6DNJ

PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research.

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CAS No.: 2857098-72-5
화학식: C₁₂₀H₁₄₆N₂₆O₃₆
분자량:2528.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

PBI-6DNJ Chemical Structure

CAS No.: 2857098-72-5

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Ki: 0.02 ± 0.002 μM (α-glucosidase from rice), 0.08 ± 0.03 μM (α-mannosidase from jack bean), 0.14 ± 0.007 μM (α-glucosidase from mice), 18.88 ± 0.30 μM (α-glucosidase from aspergilcus niger)^[1]

In Vivo

PBI-6DNJ (0-2 mg/kg, Orally, once) reduces postprandial blood glucose (PBG) levels^[1].
PBI-6DNJ (2.0 mg/kg, Orally, daily for 7 day) has good biocompatibility and no damage to mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)^[1]
Dosage:

0.5, 1.0 and 2.0 mg/kg
Administration:

Orally, once
Result:

Reduced postprandial blood glucose (PBG) level, resulting in 24.41 ± 3.02%, 34.65 ± 9.66%, and 37.77 ± 4.35% of decreases in PBG levels at the doses of 0.5, 1.0 and 2.0 mg/kg, respectively.

Animal Model:

C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)^[1]
Dosage:

2.0 mg/kg
Administration:

Orally, daily for 7 day
Result:

Resulted in increase of the level of UREA (8.63 ± 0.59 mmol/L) and decrease of the level of UA level (242.06 ± 14.77 μmol/L). No obvious differences in the levels of UREA and UA were observed. Showed a slight decrease of 0.30 mmol/L in the level of LDL. The AST level of PBI-6DNJ group (269.71 ± 39.77 U/L) was higher than that of the control group (221.38 ± 23.03 U/L), and the ALT level (59.14 ± 7.13 U/L) was lower than that of the control group (70.49 ± 8.78U/L).

Chemical Information

CAS No. 2857098-72-5
분자량 2528.60
화학식 C₁₂₀H₁₄₆N₂₆O₃₆
SMILES

OC[C@H]1[C@@H]([C@H]([C@@H](CN1CCCN2C=C(COC3=CC=C(C=C3)OC4=CC(C(N5CC6=CN(CCCN7[C@@H](CO)[C@@H]([C@H]([C@@H](C7)O)O)O)N=N6)=O)=C8C9=C4C%10=C%11C(C(C%12=O)=CC(OC%13=CC=C(C=C%13)OCC%14=CN(CCCN%15[C@H](CO)[C@H]([C@@H]([C@H](C%15)O)O)O)N=N%14)=C%11C9=C(C=C8C5=O)OC%16=CC=C(C=C%16)OCC%17=CN(CCCN(C[C@H]([C@@H]([C@H]%18O)O)O)[C@H]%18CO)N=N%17)=C(C=C%10OC%19=CC=C(OCC%20=CN(CCCN%21[C@H](CO)[C@H]([C@@H]([C@H](C%21)O)O)O)N=N%20)C=C%19)C(N%12CC%22=CN(CCCN%23[C@H](CO)[C@H]([C@@H]([C@H](C%23)O)O)O)N=N%22)=O)N=N2)O)O)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Signal Pathway Related

Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jian-XingYang, et al. Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates. European Journal of Medicinal Chemistry. 2022 November 5, 241(3):114621. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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