PD130883
PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
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- CAS No.: 123685-36-9
- 화학식: C18H15N5O3
- 분자량:349.34
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
2.4 μM
Compound: 10h
|
Tested for 50% inhibition of L1210 cell growth in vitro
Tested for 50% inhibition of L1210 cell growth in vitro
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[PMID: 2362285] |
Chemical Information
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CAS No. 123685-36-9
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분자량 349.34
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화학식 C18H15N5O3
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SMILES
O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD130883 Related Classifications
HY-118251 Related Classifications
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