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Cat. No.: HY-153512

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PHD-1-IN-3

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion.

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CAS No.: 2009345-20-2
화학식: C₁₄H₁₁N₅
분자량:249.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PHD-1-IN-3 Chemical Structure

CAS No.: 2009345-20-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
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Calculators
Help & FAQs
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Biological Activity

제품 설명

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

PHD-1-IN-3 (compound 53) acts as an MDR1 substrate in MDR1-MDCK cell monolayers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC_0-t	C_max	F
Mice^[1]	3 mg/kg	p.o.	/	40038 ng·h/mL	14.8 μM	39 %
Mice^[1]	0.5 mg/kg	i.v.	0.48 mL/min/kg	/	/	/

Chemical Information

CAS No. 2009345-20-2
분자량 249.28
화학식 C₁₄H₁₁N₅
SMILES

N#CC=1C=CC(C2=CC(N)=CC3=NC=NN32)=C(C1)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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PHD-1-IN-3

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PHD-1-IN-3 Related Classifications

HY-153512 Related Classifications