Sauvagine TFA
Based on 1 Customer Validation
Sauvagine TFA is a corticotropin-releasing factor receptor (CRFR) agonist. Sauvagine TFA activates HM-CRF receptors to stimulate intracellular cAMP accumulation, activates PC-CRF receptors to trigger associated signaling pathways, and stimulates the hypothalamic-pituitary-adrenal axis. Sauvagine TFA can be used for research on central nervous system and blood diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.96%
- 화학식: C204H347F3N56O65S1
- 분자량:4713.33
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Sauvagine (0.001-1000 nM; 20 min) TFA potently stimulates intracellular cAMP accumulation in HM-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.1 nM[1].
Sauvagine (0.001-100 nM; 20 min) TFA stimulates intracellular cAMP accumulation in PC-CRF receptor-transfected CV-1 and 293-EBNA cells with an EC50 of ~0.3 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Sauvagine (i.v.; single dose) TFA increases superior mesenteric artery flow and plasma glucose, and decrease mean arterial pressure in conscious dogs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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분자량 4713.33
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화학식 C204H347F3N56O65S1
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Color White to off-white
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Sequence
{Pry}-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2 (TFA)
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Sequence Shortening
{Pry}GPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : ≥ 100 mg/mL (21.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kishimoto T, et al. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci U S A. 1995;92(4):1108-1112. [Content Brief]
[2]. Brown MR, et al. Comparison of the biologic actions of corticotropin-releasing factor and sauvagine. Regul Pept. 1982;4(2):107-114. [Content Brief]
[3]. Montecucchi PC, et al. Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei. Int J Pept Protein Res. 1981;18(2):113-120. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2122 mL | 1.0608 mL | 2.1216 mL | 5.3041 mL |
| 5 mM | 0.0424 mL | 0.2122 mL | 0.4243 mL | 1.0608 mL | |
| 10 mM | 0.0212 mL | 0.1061 mL | 0.2122 mL | 0.5304 mL | |
| 15 mM | 0.0141 mL | 0.0707 mL | 0.1414 mL | 0.3536 mL | |
| 20 mM | 0.0106 mL | 0.0530 mL | 0.1061 mL | 0.2652 mL |
Sauvagine TFA Related Classifications
HY-P1298A Related Classifications
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