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Cat. No.: HY-106337

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SB 247083

SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a K_i of 0.41 nM. SB 247083 shows a K_i of 467 nM to endothelin-B receptor. SB 247083 shows a K_b of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 188186-61-0
화학식: C₃₄H₃₃ClN₂O₇
분자량:617.09

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SB 247083 Chemical Structure

CAS No.: 188186-61-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

ET_A

0.41 nM (Ki)

ET_B

467 nM (Ki)

All Endothelin Receptor Isoforms :

ET_A
ET_B

Chemical Information

CAS No. 188186-61-0
분자량 617.09
화학식 C₃₄H₃₃ClN₂O₇
SMILES

COC(C=C1C(OCC1)=C2)=C2C/C(C(O)=O)=C\C3=C(C4=C(C=C(C=C4)Cl)OCC5=C(C=CC=C5)C(O)=O)N(N=C3)CCCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Douglas SA, et al. Pharmacologic characterization of the novel, orally available endothelin-A--selective antagonist SB 247083. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S273-6. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
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- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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SB 247083

All Endothelin Receptor Isoforms

Biological Activity

제품 설명

IC50 & Target

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SB 247083 Related Classifications

HY-106337 Related Classifications

Bioz

Keywords

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