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Cat. No.: HY-P4096B

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scHAP-1

scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₆₀H₉₀N₁₈O₁₇
분자량:1335.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

scHAP-1 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

Animal Model:

Wistar rats (female; adjuvant-induced arthritis model)^[1]
Dosage:

0.5 mg drug/0.5 ml/250 g rat/day
Administration:

i.v.; two consecutive days
Result:

Showed a 9-fold increase in fluorescence signal in arthritic joints compared to unaffected joints in the same animals at 3 hours post-injection.

Related Protocols :

Chemical Information

분자량 1335.47
화학식 C₆₀H₉₀N₁₈O₁₇
Sequence

Ala-Leu-Ser-Gln-Ala-Phe-Arg-His-Ala-Phe-Thr-Ser
Sequence Shortening

ALSQAFRHAFTS
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vanniasinghe AS, et al. Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clin Immunol. 2014;151(1):43-54. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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