T-3861174
T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight.
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- CAS No.: 2209057-94-1
- 화학식: C26H25FN6O2
- 분자량:472.51
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
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Biological Activity
Chemical Information
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CAS No. 2209057-94-1
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분자량 472.51
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화학식 C26H25FN6O2
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SMILES
O=C(C1=NC(C)=CC(N2C([C@@](C3CC3)(C#N)CC2)=O)=C1)NCC4=CC(C5=CN(C)N=C5)=CC(F)=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T-3861174 Related Classifications
HY-117938 Related Classifications
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