TPCA-1 (Standard)
TPCA-1 (Standard) is the analytical standard of TPCA-1 (HY-10074). This product is intended for research and analytical applications. TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 507475-17-4
- 화학식: C12H10FN3O2S
- 분자량:279.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- 순도&문서
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Help & FAQs
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HY-10074
TPCA-1IKK-2 Inhibitor -
HY-13687
IKK 16IKK Inhibitor -
HY-18008
PS-1145Apoptosis Inducer -
HY-10257
BAY 11-7085NF-κB Activation Inhibitor -
HY-13453
BAY 11-7082IκBα/NF-κB Inhibitor -
HY-10172
IMD-0354IKKβ Inhibitor -
HY-13802
SC-514IKK Inhibitor -
HY-15473
MLN120BIKKβ Inhibitor -
HY-10519
BMS-345541IKK-1/IKK-2 Inhibitor -
HY-10518
BMS-345541 hydrochlorideIKK-1/IKK-2 Inhibitor -
HY-14393
EmodinNatural Anthraquinone -
HY-B0713
AmlexanoxIKK Inhibitor
Product Information
Information
신청
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 507475-17-4
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분자량 279.29
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화학식 C12H10FN3O2S
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SMILES
O=C(C1=C(NC(N)=O)SC(C2=CC=C(F)C=C2)=C1)N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Sachse F, et al. IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro.Rhinology. 2011 Jun;49(2):168-73. [Content Brief]
[2]. Podolin PL, et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflamm [Content Brief]
[3]. Nan J, et al. TPCA-1 is a direct dual inhibitor of STAT3 and NF-κB and regresses mutant EGFR-associated human non-small cell lung cancers. Mol Cancer Ther. 2014 Mar;13(3):617-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPCA-1 (Standard) Related Classifications
HY-10074R Related Classifications
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