UCK2 Inhibitor-2
Based on 1 Customer Validation
UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.25%
- CAS No.: 866842-71-9
- 화학식: C28H23N3O4S
- 분자량:497.56
-
보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 3.8 µM (UCK2)[1]
In Vitro
UCK2 Inhibitor-2 (compound 20874830) shows 52% inhibition of uridine salvage in K562 cells at a concentration of 50 µM. The inhibition of DHODH increases uridine salvage, while, UCK2 inhibitor UCK2 Inhibitor-2 (compound 20874830) can suppress this increase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 866842-71-9
-
Appearance Solid
-
분자량 497.56
-
화학식 C28H23N3O4S
-
Color Off-white to light yellow
-
SMILES
O=C(C1=CC(NC(CSC2=C3CC4=C(C(C)=CC=C4)OC3=NC(C5=CC=C(C)C=C5)=N2)=O)=CC=C1)O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocol
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
-
Data Sheet (269 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UCK2 Inhibitor-2 Related Classifications
HY-148395 Related Classifications
Powered by Bioz