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Cat. No.: HY-182672

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VT101

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 65194-64-1
화학식: C₁₄H₂₀N₂O₄S
분자량:312.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

VT101 Chemical Structure

CAS No.: 65194-64-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VT101 is a TEAD inhibitor with an IC₅₀ of 454 nM. VT101 is applicable for cancer research^[1].

IC₅₀ & Target

^[1]

TEAD

454 nM (IC₅₀)

All YAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2052	IC₅₀	3 μM Compound: 39; VT101	Antiproliferative activity against human NCI-H2052 cells Antiproliferative activity against human NCI-H2052 cells	[PMID: 39047607]

In Vitro

VT101 inhibits YAP-mediated transcriptional activity with an IC₅₀ of 454 nM in a luciferase reporter assay but does not significantly inhibit the growth of NCI-H2052 cells (IC₅₀ > 3 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 65194-64-1
분자량 312.38
화학식 C₁₄H₂₀N₂O₄S
SMILES

O=C(C1=CC(S(=O)(N)=O)=CC=C1NC2CCCCC2)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lou J, et al. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem. 2022;243:114684. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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