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Cat. No.: HY-119363

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VU6009453

VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC₅₀ of 383 nM. VU6009453 can be used for research on neurological diseases.

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CAS No.: 2148929-11-5
화학식: C₂₁H₂₁ClN₄O₂
분자량:396.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VU6009453 Chemical Structure

CAS No.: 2148929-11-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC₅₀ of 383 nM. VU6009453 can be used for research on neurological diseases^[1].

IC₅₀ & Target^[1]

mAChR4

383 nM (EC₅₀)

All mAChR Isoforms :

Chemical Information

CAS No. 2148929-11-5
분자량 396.88
화학식 C₂₁H₂₁ClN₄O₂
SMILES

O=C(NC1CN(C2=CC(=NC=C2Cl)OC)C1)C=3C=CC=4N=C(C=C(C4C3)C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Long MF, et al. Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorg Med Chem Lett. 2017 Nov 15;27(22):4999-5001. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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VU6009453

All mAChR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

VU6009453 Related Classifications

HY-119363 Related Classifications