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Cat. No.: HY-181891

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XAT-13

XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3107904-58-2
화학식: C₂₀H₁₆O₅
분자량:336.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

XAT-13 Chemical Structure

CAS No.: 3107904-58-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

MRGPRX2

All Calcium Channel Isoforms :

In Vitro

XAT-13 (up to 100 μmol/L) shows no cytotoxicity in LAD2 cells^[1].
XAT-13 (25-100 μmol/L) inhibits C48/80-induced β-hexosaminidase release from LAD2 cells in a dose-dependent manner, with an IC₅₀ of 57.27 ± 0.13 μmol/L, and is more potent than Imperatorin (HY-N0285)^[1].
XAT-13 (25-100 μmol/L) dose-dependently inhibits C48/80-induced intracellular calcium influx in MRGPRX2-HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XAT-13 (4-16 mg/kg; p.o.) exhibits an inhibitory effect on C48/80-induced local allergy in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C48/80-induced local allergy^[1]
Dosage:

4, 8, 16 mg/kg
Administration:

p.o.
Result:

Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.

Chemical Information

CAS No. 3107904-58-2
분자량 336.34
화학식 C₂₀H₁₆O₅
SMILES

O=C1OC2=C(OCCCOC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang W, et al. Furanocoumarin derivatives inhibit MRGPRX2-mediated pseudo-allergy. Bioorg Med Chem Lett. 2026;135:130589. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
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XAT-13

All Calcium Channel Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

XAT-13 Related Classifications

HY-181891 Related Classifications