2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. L-731988

L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED50 values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.

For research use only. We do not sell to patients.

L-731988

L-731988 Chemical Structure

CAS No. : 251922-77-7

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L-731988 Related Antibodies

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Description

L-731988 is an inhibitor targeting HIV-1 integrase. L-731988 inhibits HIV-1 replication by blocking integrase function. L-731988 exhibits ED50 values ranging from 0.5 μM to 3.14 μM against various HIV-1 isolates. L-731988 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 CC50
10 μM
Compound: L-731988
Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay
[PMID: 19026554]
In Vitro

L-731988 (0.5-5.0 μM) suppresses RT activity of HIV-1 primary isolates in PBLs in a dose-dependent manner[1].
L-731988 inhibits replication of diverse primary HIV-1 isolates in PBLs, with ED50 values ranging from 0.544 to 3.14 μM; most isolates show less-than-twofold differences in susceptibility relative to HIVLAI, while HIV92RW009 exhibits a sixfold reduction in susceptibility[1].
L-731988 inhibits HIV-1 replication in MT-2 cells with ED50 values ranging from 0.505 to 1.6 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-731988 Related Antibodies
Molecular Weight

289.26

Formula

C15H12FNO4
CAS No.
SMILES

O=C(C(CC(C1=CC=CN1CC2=CC=C(C=C2)F)=O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-731988 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-731988251922-77-7L731988L 731988HIV IntegraseHIV integraseclade A/E recombinant isolatesgroup M clades BHIV-92RW009 isolatePBLsgroup M clades CHIV-1 isolatesgroup M clades AMT2 cellsgroup OInhibitorinhibitorinhibit

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