Lanperisone
Lanperisone is a novel oral muscle relaxant with anticancer activity. Lanperisone produces non-apoptotic cell death by inhibiting monosynaptic and polysynaptic reflex potentials. Lanperisone is also believed to play an important role in the dysregulation of iron metabolism and antioxidant systems to modulate processes associated with ischemic stroke.
For research use only. We do not sell to patients.
- CAS No.: 116287-14-0
- Formula: C15H18F3NO
- Molecular Weight:285.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MEF | IC50 |
4 μM
Compound: 7
|
Cytotoxicity against MEF harboring KRAS G12D mutant by ATP-based cell viability assay
Cytotoxicity against MEF harboring KRAS G12D mutant by ATP-based cell viability assay
|
[PMID: 23566315] |
| MEF | IC50 |
4 μM
Compound: 7
|
Antiproliferative activity against mouse MEF cells expressing KRAS G12D mutant assessed as reduction in cell viability incubated for 48 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against mouse MEF cells expressing KRAS G12D mutant assessed as reduction in cell viability incubated for 48 hrs by CellTiter-Glo luminescent assay
|
[PMID: 36332549] |
| MEF | IC50 |
4 μM
Compound: Lanperisone
|
Cytotoxicity against MEF expressing K-rasG12D after 48 hrs by CellTiter-Glo assay
Cytotoxicity against MEF expressing K-rasG12D after 48 hrs by CellTiter-Glo assay
|
[PMID: 22297109] |
Chemical Information
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CAS No. 116287-14-0
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Molecular Weight 285.30
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Formula C15H18F3NO
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SMILES
O=C([C@@H](CN1CCCC1)C)C2=CC=C(C=C2)C(F)(F)F
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Synonyms
NK433 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)