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Lepodisiran sodium

(Synonyms: LY3819469 sodium)

Lepodisiran (LY3819469) sodium is a GalNAc-conjugated, injectable small interfering RNA lipid-lowering agent characterized by rapid hepatic uptake and long-lasting effects. Lepodisiran sodium targets the hepatic LPA gene and degrades apolipoprotein (a) mRNA to silence its expression, thereby effectively reducing the production of apolipoprotein (a) and serum lipoprotein (a) in a dose-dependent manner. Lepodisiran sodium can be used in research related to atherosclerotic cardiovascular disease.

For research use only. We do not sell to patients.

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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Lepodisiran sodium Chemical Structure
    Lepodisiran sodium Chemical Structure
CAS No.: 2766131-24-0
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Use of MCE Products

All Apolipoprotein Isoforms

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  • Lepodisiran sodium Chemical Structure
    Lepodisiran sodium Chemical Structure RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)A-Am-Gm-Cm-(2'-deoxy-2'-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), sodium salt, complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) sodium salt (1:22:1:35)
    1/16
  • RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)A-Am-Gm-Cm-(2'-deoxy-2'-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), sodium salt, complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) sodium salt (1:22:1:35)