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Lepodisiran sodium

(Synonyms: LY3819469 sodium)

Lepodisiran (LY3819469) sodium is a GalNAc-conjugated small interfering RNA lipid-lowering agent. Lepodisiran sodium targets the hepatic LPA gene and degrades apolipoprotein (a) mRNA to silence its expression, thereby effectively reducing the production of apolipoprotein (a) and serum lipoprotein (a) in a dose-dependent manner. Lepodisiran sodium can be used in studies related to atherosclerotic cardiovascular disease.

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  • Lepodisiran sodium Chemical Structure
    Lepodisiran sodium Chemical Structure
CAS. Nr.: 2766131-24-0
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  • Lepodisiran sodium Chemical Structure
    Lepodisiran sodium Chemical Structure RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)A-Am-Gm-Cm-(2'-deoxy-2'-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), sodium salt, complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) sodium salt (1:22:1:35)
    1/16
  • RNA, ([4'-de(hydroxymethyl)-4'-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Cm-Cm-(2'-deoxy-2'-fluoro)A-Am-Gm-Cm-(2'-deoxy-2'-fluoro)U-Um-Gm-Gm-Cm-Am-Am-sp-Gm-sp-Gm), sodium salt, complex with RNA (Um-sp-Um-Gm-Cm-Cm-Am-Am-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Gm-Gm-Um-Cm-Am-Um-Cm-Um-Am-Gm-Cm-Am-Gm-Cm-Cm-Gm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm) sodium salt (1:22:1:35)