Limnetrelvir
Based on 1 Customer Validation
Limnetrelvir (ABBV-903) is a MPro inhibitor. Limnetrelvir could be used in antiviral research.
For research use only. We do not sell to patients.
- Purity : 99.81%
- CAS No.: 2923500-04-1
- Formula: C27H23F4N5O4
- Molecular Weight:557.50
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
Description
Chemical Information
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CAS No. 2923500-04-1
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Appearance Solid
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Molecular Weight 557.50
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Formula C27H23F4N5O4
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Color Off-white to light yellow
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SMILES
[H][C@]1(CCN(C1)C2=C(C=C(C=C2C(F)(F)F)C#N)C(N3CCOCC3)=O)NC(C4=CC(NC5=C4C=CC=C5F)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (89.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7937 mL | 8.9686 mL | 17.9372 mL | 44.8430 mL |
| 5 mM | 0.3587 mL | 1.7937 mL | 3.5874 mL | 8.9686 mL | |
| 10 mM | 0.1794 mL | 0.8969 mL | 1.7937 mL | 4.4843 mL | |
| 15 mM | 0.1196 mL | 0.5979 mL | 1.1958 mL | 2.9895 mL | |
| 20 mM | 0.0897 mL | 0.4484 mL | 0.8969 mL | 2.2422 mL | |
| 25 mM | 0.0717 mL | 0.3587 mL | 0.7175 mL | 1.7937 mL | |
| 30 mM | 0.0598 mL | 0.2990 mL | 0.5979 mL | 1.4948 mL | |
| 40 mM | 0.0448 mL | 0.2242 mL | 0.4484 mL | 1.1211 mL | |
| 50 mM | 0.0359 mL | 0.1794 mL | 0.3587 mL | 0.8969 mL | |
| 60 mM | 0.0299 mL | 0.1495 mL | 0.2990 mL | 0.7474 mL | |
| 80 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5605 mL |