Polyketides

Jaceidin is a promising lead molecule for potent VEGFR inhibitor with excellent membrane permeability and oral bioavailability. Jaceidin exhibits anti-tumor activities.

2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran (Compound 4) is a compound isolated from the roots of Erythrina herbacea.

AChE-IN-17 (compound 1) is a potent AChE inhibitor with an IC₅₀ value of 28.98 μM. AChE-IN-17 can significantly prevent H₂O₂-induced PC12 cell death, exhibiting excellent neuroprotective effect. AChE-IN-17 can be used for researching neurodegenerative diseases (NDs).

Pikromycin is a macrolide antibiotic that has been found in S. venezuelae and active against E. coli, S. aureus and B. subtilis.

Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5.

2'',4''-Di-O-(Z-p-Coumaroyl)afzelin (compound 9) is a compound isolated from the leaf extract of Machilusphilippinense Merr..

Isowigtheone is a cytotoxic isoflavone compound isolated from the root barks of Brosimum utile. Isowigtheone has the potential for the research of cancer diseases.

Pashanone is a compound isolated from Lindera erytbrocarpa Makino (Lauraceae).

5-n-Tricosylresorcinolthe is the first cyst lipid. 5-n-Tricosylresorcinolthe has metahydroxyl group which allows it to self-associate forming a staggered-chain conformation in which the polar head groups have heaxagonal symmetry. 5-n-Tricosylresorcinolthe reduces hydrogen peroxide-induced DNA damage.

XA-E is a compound purified from a methanol-ethyl acetate extract from A. keiskei. XA-E displays anti-ZIKV activity with an IC₅₀ value of 22.0 µM.

Carviolin is a compound isolated from the mycelia of the ascomycete Neobulgaria pura. Carviolin inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. Carviolin exhibits moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.

(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains. And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato.

Viscidulin I is found in Scutellaria baicalensis Georgi.

Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.

Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti.

Petunidin-3-O-galactoside chloride is a flavonoid compound with antioxidant capacity.

Pratensein-7-O-β-D-glucopyranoside is a new isoflavone.

Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside is a bioactive constituent that can be found in the seeds of Lepidium apetalum Willd. Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside exhibits significant triglyceride (TG)-lowering effects in HepG2 cells.

Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor.

Quercetin 3-O-sophoroside-7-O-rhamnoside is a flavonoid found in sea buckthorn berries.