2. Anti-infection
  3. SARS-CoV
  4. Lomtegovimab

Lomtegovimab  (Synonyms: BI 767551; DZIF-10c)

Cat. No.: HY-P99710

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Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19.

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Lomtegovimab Chemical Structure

Lomtegovimab Chemical Structure

CAS No. : 2550869-33-3

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Lomtegovimab Related Antibodies

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Description

Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19[1][2].

In Vitro

Lomtegovimab targets the RBD of SARS-CoV-2 S with a KD value of 1.09 nM[2].
Lomtegovimab shows neutralizing activity with IC50s of 0.001, 0.001, 0.010 µg/mL for SARS-CoV-2 S D614G, SARS-CoV-2 S B.1.1.7, SARS-CoV-2 BavPat1 (B.1), respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lomtegovimab Related Antibodies
In Vivo

Lomtegovimab (40 mg/kg; i.p. or i.n.; once; three days before infection) protects hACE2-transduced mice from infection with SARS-CoV-2[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (Ad_ACE2-mCherry)[2]
Dosage: 40 mg/kg
Administration: I.p. or I.n.; once; three days before infection
Result: Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.
Clinical Trial
CAS No.
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[Lomtegovimab]
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Lomtegovimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lomtegovimab2550869-33-3BI 767551 DZIF-10cBI767551BI-767551SARS-CoVSARS coronavirusSARS-COV-2antiviralhACE2neutralizing antibodyInhibitorinhibitorinhibit

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