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Cat. No.: HY-182780

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LSPN925

LSPN925 is an anticancer agent. LSPN925 exhibits cytotoxic and antiproliferative activities against tumor cells. LSPN925 has predicted oral bioavailability, low risks of hepatotoxicity and acute toxicity, and no risk of cardiotoxicity. LSPN925 can be used for the research of ovarian cancer, melanoma and breast cancer.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₂N₂O₆
Molecular Weight:434.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSPN925 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

LSPN925 (48 h) inhibits the viability of A2780, A375 and MCF-7 cancer cells^[1].
LSPN925 (48 h) alters the morphology and reduces the viability of A2780 ovarian cancer cells, as evidenced by increased membrane damage and decreased cell density^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A2780 ovarian cancer cells, A375 human melanoma cells, MCF-7 breast cancer cells, MRC-5 non-cancerous lung cells
Concentration:

/
Incubation Time:

48 h
Result:

Exhibited dose-dependent cytotoxicity against A2780, A375, and MCF-7 cancer cell lines, with IC₅₀ values of 29.59 μM, 65.15 μM, and 81.20 μM, respectively.
Showed no significant cytotoxicity in non-cancerous MRC-5 cells (IC₅₀ > 100 μM).

Chemical Information

Molecular Weight 434.44
Formula C₂₄H₂₂N₂O₆
SMILES

CC1=CC=C(OC(C(C(N2)=C(C(OCC)=O)C(C3=CC(OC)=CC=C3)NC2=O)=C4)=O)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dos Santos JRN, et al. Coumarin-dihydropyrimidinone hybrids as promising agents against ovarian cancer: synthesis, SAR, and in silico evaluation. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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