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Cat. No.: HY-161360

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LXQ-217

LXQ-217 is an oral active SHP2 inhibitor with the IC₅₀ of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro.

For research use only. We do not sell to patients.

CAS No.: 2524718-79-2
Formula: C₂₄H₂₀Br₂N₂O₅
Molecular Weight:576.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LXQ-217 Chemical Structure

CAS No.: 2524718-79-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

LXQ-217 is an oral active SHP2 inhibitor with the IC₅₀ of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro^[1].

In Vitro

LXQ-217 (72 h) inhibits cell growth of A549, HCT116, HepG2 and MDA-MB-231 cells with the IC₅₀ values of 2.06, 3.88, 4.53, and 5.13 μM^[1].
LXQ-217 (2.5, 5, 10 μM, 7 days) decreases the clonogenic number and formation rate of A549 cells^[1].
LXQ-217 (1.25, 2.5 μM, 24 h) inhibits the migration of A549 cells^[1].
LXQ-217 (2.5, 5, 10 μM, 3 h) increases in the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

A549 cells
Concentration:

1.25 and2.5 μM
Incubation Time:

72 h
Result:

Inhibited the migration of A549 cells.

Western Blot Analysis^[1]

Cell Line:

A549 cells
Concentration:

2.5, 5 and 10 μM
Incubation Time:

3 h
Result:

Increased the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells.

In Vivo

LXQ-217 (50, 100mg/kg; Oral administration for 14 days) inhibites the growth of A549 cell xenograft model constructed based on BALB/c-nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 cell xenograft model constructed based on BALB/c-nude mice^[1]
Dosage:

50 or 100mg/kg
Administration:

Oral administration for 14 days
Result:

Lowered tumor weight and volume of mice.

Chemical Information

CAS No. 2524718-79-2
Molecular Weight 576.23
Formula C₂₄H₂₀Br₂N₂O₅
SMILES

CCOC(C=C1)=CC=C1OC2=CC=C(C3=NN(C=O)C(C4=C(Br)C(Br)=C(O)C(O)=C4)C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun H, et al. Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo. Chem Biodivers. Published online February 20, 2024. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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