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Cat. No.: HY-146275

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LXRβ agonist-3

LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma.

For research use only. We do not sell to patients.

CAS No.: 2416049-12-0
Formula: C₃₀H₃₃N₃O₆S
Molecular Weight:563.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LXRβ agonist-3 Chemical Structure

CAS No.: 2416049-12-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EC₅₀: 0.095 ± 0.012 μM (LXRβ) 0.277 ± 0.066 μM (LXRα)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A 172	IC₅₀	6.03 μM Compound: 4-13rr	Antiproliferative activity against human A 172 cells measured after 7 days by CCK8 assay Antiproliferative activity against human A 172 cells measured after 7 days by CCK8 assay	[PMID: 32248003]
U-251	IC₅₀	2.23 μM Compound: 4-13rr	Antiproliferative activity against human U-251 cells measured after 7 days by CCK8 assay Antiproliferative activity against human U-251 cells measured after 7 days by CCK8 assay	[PMID: 32248003]
U-87MG ATCC	IC₅₀	1.78 μM Compound: 4-13rr	Antiproliferative activity against human U87 cells overexpressing EGFR variant III measured after 7 days by CCK8 assay Antiproliferative activity against human U87 cells overexpressing EGFR variant III measured after 7 days by CCK8 assay	[PMID: 32248003]

In Vivo

LXRβ agonist-3 (compound 4-13) (BALB/c mice, 50 mg/kg, IP, daily for 15 days) significantly reduces glioblastoma tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2416049-12-0
Molecular Weight 563.66
Formula C₃₀H₃₃N₃O₆S
SMILES

O=C1[C@]2(C3=CC=CC=C3N1)[C@@H](C4=CC(NC5=CC(S(C)(=O)=O)=C(C=C5)CO)=CC=C4)N(CC2)C(OC(C)(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen H, Chen Z, Zhang Z, Li Y, Zhang S, Jiang F, Wei J, Ding P, Zhou H, Gu Q, Xu J. Discovery of new LXRβ agonists as glioblastoma inhibitors. Eur J Med Chem. 2020 May 15;194:112240. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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