Lycorine hydrochloride monohydrate
Based on 19 publication(s) in Google Scholar
Lycorine Hydrochloride Monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 6150-58-9
- Formula: C16H20ClNO5
- Molecular Weight:341.79
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lycorine hydrochloride monohydrate
More- J Nanobiotechnology. 2026 Mar 22;24(1):405. [Abstract]
- J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
- Pharmacol Res. 2022 Jan:175:105985. [Abstract]
- Int J Mol Med. 2022 Dec;50(6):145. [Abstract]
- Eur J Pharmacol. 2023 Dec 15:961:176162. [Abstract]
- Int J Mol Sci. 2025 Jun 3;26(11):5358. [Abstract]
- Mol Med Rep. 2024 Mar;29(3):48. [Abstract]
- Microorganisms. 2022 Oct 21;10(10):2089. [Abstract]
- Antiviral Res. 2024 Aug:228:105955. [Abstract]
- Pest Manag Sci. 2026 Jun 20. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- J Nat Med. 2026 Mar 9. [Abstract]
- Ann Hematol. 2026 Jan 17;105(1):24. [Abstract]
- Ann Hematol. 2023 May;102(5):1073-1086. [Abstract]
- Oncol Lett. 2021 Nov;22(5):781. [Abstract]
- Mol Biol. 2026 Jan 20.
- SSRN. 2025 Dec 19.
- Research Square Preprint. 2022 Feb.
- Research Square Preprint. 2022 Jan.
Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Flow Cytometry
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In Vivo Efficacy Study
Biological Activity
Chemical Information
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CAS No. 6150-58-9
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Appearance Solid
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Molecular Weight 341.79
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Formula C16H20ClNO5
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Color White to off-white
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SMILES
O[C@H]1[C@]2([H])[C@]3([H])N(CCC3=C[C@@H]1O)CC4=CC(OCO5)=C5C=C24.O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (19)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway. [Abstract]2026 Mar 22;24(1):405. PMID: 41866523 -
J Exp Clin Cancer Res
Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. [Abstract]2022 Mar 30;41(1):116. PMID: 35354475
Lycorine hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Immunoblot analysis of SCAP protein expression at different concentrations. PLC-SR cells (control) were treated with Lycorine (Ly) (1, 2, 4 μM) alone, Sorafenib (Sora) alone or a combination of Lycorine and Sorafenib (Ly + Sora).
Lycorine hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
The combined use of Lycorine (1, 2, 4 μM) and Sorafenib significantly inhibited the proliferation of PLC-SR cells.
Lycorine hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Lycorine (1, 2, 4 μM) combined with Sorafenib decelerated the migration and invasion of sorafenib-resistant HCC cells.
Lycorine hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Flow cytometry analysis indicated that when Lycorine (1, 2, 4 μM) was combined with Sorafenib, the percentage of S phase cells was decreased, and apoptosis was significantly increased.
Lycorine hydrochloride monohydrate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Lycorine (10 mg/kg, i.g.) combined with Sorafenib can reduce the tumor volume in mice.
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Pharmacol Res
Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy. [Abstract]2022 Jan:175:105985. PMID: 34863821 -
Int J Mol Med
Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. [Abstract]2022 Dec;50(6):145. PMID: 36367172 -
Eur J Pharmacol
Lycorine eliminates B-cell acute lymphoblastic leukemia cells by targeting PSAT1 through the serine/glycine metabolic pathway. [Abstract]2023 Dec 15:961:176162. PMID: 37951487 -
Int J Mol Sci
Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [Abstract]2025 Jun 3;26(11):5358. PMID: 40508167 -
Mol Med Rep
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway. [Abstract]2024 Mar;29(3):48. PMID: 38275129 -
Microorganisms
Screening of Endophytic Bacteria of Leucojum aestivum 'Gravety Giant' as a Potential Source of Alkaloids and as Antagonist to Some Plant Fungal Pathogens. [Abstract]2022 Oct 21;10(10):2089. PMID: 36296365 -
Antiviral Res
Discovery of hepatitis B virus subviral particle biogenesis inhibitors from a bioactive compound library. [Abstract]2024 Aug:228:105955. PMID: 38964614 -
Pest Manag Sci
Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura. [Abstract]2026 Jun 20. PMID: 42322590 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
J Nat Med
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis. [Abstract]2026 Mar 9. PMID: 41801295 -
Ann Hematol
Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1. [Abstract]2026 Jan 17;105(1):24. PMID: 41545705 -
Ann Hematol
Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5. [Abstract]2023 May;102(5):1073-1086. PMID: 36943465 -
Oncol Lett
Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells. [Abstract]2021 Nov;22(5):781. PMID: 34594422 -
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Solvent & Solubility
DMSO : 33.33 mg/mL (97.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (249 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9258 mL | 14.6289 mL | 29.2577 mL | 73.1443 mL |
| 5 mM | 0.5852 mL | 2.9258 mL | 5.8515 mL | 14.6289 mL | |
| 10 mM | 0.2926 mL | 1.4629 mL | 2.9258 mL | 7.3144 mL | |
| 15 mM | 0.1951 mL | 0.9753 mL | 1.9505 mL | 4.8763 mL | |
| 20 mM | 0.1463 mL | 0.7314 mL | 1.4629 mL | 3.6572 mL | |
| 25 mM | 0.1170 mL | 0.5852 mL | 1.1703 mL | 2.9258 mL | |
| 30 mM | 0.0975 mL | 0.4876 mL | 0.9753 mL | 2.4381 mL | |
| 40 mM | 0.0731 mL | 0.3657 mL | 0.7314 mL | 1.8286 mL | |
| 50 mM | 0.0585 mL | 0.2926 mL | 0.5852 mL | 1.4629 mL | |
| 60 mM | 0.0488 mL | 0.2438 mL | 0.4876 mL | 1.2191 mL | |
| 80 mM | 0.0366 mL | 0.1829 mL | 0.3657 mL | 0.9143 mL |
Lycorine hydrochloride monohydrate Related Classifications
HY-N0288A Related Classifications
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