m-PEG25-Propargyl

Cat. No.: HY-130901: Data Sheet Handling Instructions
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m-PEG25-Propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG25-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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m-PEG25-Propargyl Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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Biological Activity
Purity & Documentation
References
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Description

m-PEG25-Propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. m-PEG25-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1127.35

Formula

C₅₂H₁₀₂O₂₅

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (88.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8870 mL	4.4352 mL	8.8704 mL
5 mM	0.1774 mL	0.8870 mL	1.7741 mL
10 mM	0.0887 mL	0.4435 mL	0.8870 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8870 mL	4.4352 mL	8.8704 mL	22.1759 mL
	5 mM	0.1774 mL	0.8870 mL	1.7741 mL	4.4352 mL
	10 mM	0.0887 mL	0.4435 mL	0.8870 mL	2.2176 mL
	15 mM	0.0591 mL	0.2957 mL	0.5914 mL	1.4784 mL
	20 mM	0.0444 mL	0.2218 mL	0.4435 mL	1.1088 mL
	25 mM	0.0355 mL	0.1774 mL	0.3548 mL	0.8870 mL
	30 mM	0.0296 mL	0.1478 mL	0.2957 mL	0.7392 mL
	40 mM	0.0222 mL	0.1109 mL	0.2218 mL	0.5544 mL
	50 mM	0.0177 mL	0.0887 mL	0.1774 mL	0.4435 mL
	60 mM	0.0148 mL	0.0739 mL	0.1478 mL	0.3696 mL
	80 mM	0.0111 mL	0.0554 mL	0.1109 mL	0.2772 mL