Mal-amido-PEG2-C2-acid

Cat. No.: HY-42151 Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG2-C2-acid Chemical Structure

CAS No. : 756525-98-1

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Free Sample (0.1 - 0.5 mg)		Apply Now
250 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
1 g	USD 230	In-stock	Estimated Time of Arrival: December 31
5 g	USD 800	In-stock	Estimated Time of Arrival: December 31
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Description

Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

328.32

Formula

C₁₄H₂₀N₂O₇

CAS No.

756525-98-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (304.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0458 mL	15.2290 mL	30.4581 mL
5 mM	0.6092 mL	3.0458 mL	6.0916 mL
10 mM	0.3046 mL	1.5229 mL	3.0458 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0458 mL	15.2290 mL	30.4581 mL	76.1452 mL
	5 mM	0.6092 mL	3.0458 mL	6.0916 mL	15.2290 mL
	10 mM	0.3046 mL	1.5229 mL	3.0458 mL	7.6145 mL
	15 mM	0.2031 mL	1.0153 mL	2.0305 mL	5.0763 mL
	20 mM	0.1523 mL	0.7615 mL	1.5229 mL	3.8073 mL
	25 mM	0.1218 mL	0.6092 mL	1.2183 mL	3.0458 mL
	30 mM	0.1015 mL	0.5076 mL	1.0153 mL	2.5382 mL
	40 mM	0.0761 mL	0.3807 mL	0.7615 mL	1.9036 mL
	50 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.5229 mL
	60 mM	0.0508 mL	0.2538 mL	0.5076 mL	1.2691 mL
	80 mM	0.0381 mL	0.1904 mL	0.3807 mL	0.9518 mL
	100 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.7615 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-amido-PEG2-C2-acid756525-98-1Inhibitorinhibitorinhibit

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Mal-amido-PEG2-C2-acid