Mal-amido-PEG6-acid

Name: Mal-amido-PEG6-acid
Brand: MedChemExpress
SKU: HY-130399
Rating: 4.5 (0 reviews)

Cat. No.: HY-130399 Purity: 99.33%: Data Sheet
COA

SDS
Handling Instructions
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Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG6-acid Chemical Structure

CAS No. : 1334177-79-5

Size	Stock	Quantity
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

504.53

Formula

C₂₂H₃₆N₂O₁₁

CAS No.

1334177-79-5

Appearance

Solid

Color

Off-white to gray

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (198.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (198.20 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9820 mL	9.9102 mL	19.8204 mL
5 mM	0.3964 mL	1.9820 mL	3.9641 mL
10 mM	0.1982 mL	0.9910 mL	1.9820 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (240 KB) HNMR (279 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.9820 mL	9.9102 mL	19.8204 mL	49.5511 mL
	5 mM	0.3964 mL	1.9820 mL	3.9641 mL	9.9102 mL
	10 mM	0.1982 mL	0.9910 mL	1.9820 mL	4.9551 mL
	15 mM	0.1321 mL	0.6607 mL	1.3214 mL	3.3034 mL
	20 mM	0.0991 mL	0.4955 mL	0.9910 mL	2.4776 mL
	25 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9820 mL
	30 mM	0.0661 mL	0.3303 mL	0.6607 mL	1.6517 mL
	40 mM	0.0496 mL	0.2478 mL	0.4955 mL	1.2388 mL
	50 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	60 mM	0.0330 mL	0.1652 mL	0.3303 mL	0.8259 mL
	80 mM	0.0248 mL	0.1239 mL	0.2478 mL	0.6194 mL
	100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.4955 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.