2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Mal-L-PA-NH-Boc

Mal-L-PA-NH-Boc  (Synonyms: mDPR(boc); (S)-MALEOYL-DPR(BOC)-OH·DCHA)

Cat. No.: HY-41919 Purity: 99.30%
COA
SDS
Handling Instructions Technical Support

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Mal-L-PA-NH-Boc

Mal-L-PA-NH-Boc 화학구조

CAS No. : 1491152-23-8

사이즈 가격 재고 수량
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g   견적 받기  
5 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Mal-L-PA-NH-Boc Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

View All Isoforms
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Mal-L-PA-NH-Boc is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-L-PA-NH-Boc Related Antibodies
분자량

284.27

화학식

C12H16N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C1)N([C@@H](CNC(OC(C)(C)C)=O)C(O)=O)C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (351.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5178 mL 17.5889 mL 35.1778 mL
5 mM 0.7036 mL 3.5178 mL 7.0356 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.30%

SDS (393 KB)

COA (254 KB) HNMR (135 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5178 mL 17.5889 mL 35.1778 mL 87.9446 mL
5 mM 0.7036 mL 3.5178 mL 7.0356 mL 17.5889 mL
10 mM 0.3518 mL 1.7589 mL 3.5178 mL 8.7945 mL
15 mM 0.2345 mL 1.1726 mL 2.3452 mL 5.8630 mL
20 mM 0.1759 mL 0.8794 mL 1.7589 mL 4.3972 mL
25 mM 0.1407 mL 0.7036 mL 1.4071 mL 3.5178 mL
30 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9315 mL
40 mM 0.0879 mL 0.4397 mL 0.8794 mL 2.1986 mL
50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7589 mL
60 mM 0.0586 mL 0.2931 mL 0.5863 mL 1.4657 mL
80 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8794 mL
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Mal-L-PA-NH-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-L-PA-NH-Boc1491152-23-8mDPR(boc) (S)-MALEOYL-DPR(BOC)-OH·DCHAADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Inquiry Information

상품명:
Mal-L-PA-NH-Boc
Cat. No.:
HY-41919
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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