MC-GGFG-Eribulin
MC-GGFG-Eribulin is a linker-payload of a tubulin inhibitor-based cytotoxic agent with an N-substituted maleimide group, conjugated via the MC-GGFG linker. MC-GGFG-Eribulin reacts with the thiol groups of reduced antibodies or antigen-binding fragments to form antibody-drug conjugates. MC-GGFG-Eribulin is applicable for cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2907719-42-8
- Formula: C65H88N6O18
- Molecular Weight:1241.42
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
MC-GGFG-Eribulin can be conjugated with antibodies to prepare ADC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2907719-42-8
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Appearance Solid
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Molecular Weight 1241.42
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Formula C65H88N6O18
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Color White to off-white
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SMILES
O=C(CNC(CCCCCN1C(C=CC1=O)=O)=O)NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NC[C@@H](O)C[C@@H](O[C@H]3C[C@H]4O[C@@H](CC[C@@H]5O6)C[C@@H](C)C4=C)[C@H](OC)[C@H]3CC(C[C@@H]7O[C@H]([C@H](O8)[C@H](O[C@H](C9)[C@@H]%10O[C@]98CC[C@H]6CC5=C)[C@H]%10O%11)[C@@H]%11CC7)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (40.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8055 mL | 4.0276 mL | 8.0553 mL | 20.1382 mL |
| 5 mM | 0.1611 mL | 0.8055 mL | 1.6111 mL | 4.0276 mL | |
| 10 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0138 mL | |
| 15 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL | |
| 20 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0069 mL | |
| 25 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8055 mL | |
| 30 mM | 0.0269 mL | 0.1343 mL | 0.2685 mL | 0.6713 mL | |
| 40 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5035 mL |
MC-GGFG-Eribulin Related Classifications
HY-184371 Related Classifications
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