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Melanin probe-1 

Cat. No.: HY-136404 Purity: 98.06%
Handling Instructions

Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability.

For research use only. We do not sell to patients.

Melanin probe-1 Chemical Structure

Melanin probe-1 Chemical Structure

CAS No. : 1420844-62-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1].

In Vivo

Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1].
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1].

Animal Model: C57BL/6 mice bearing B16F10 murine melanomas[1]
Dosage: 3.7 MBq (100 μCi)
Administration: Tail vein
Result: The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively.
Molecular Weight

239.29

Formula

C₁₂H₁₈FN₃O

CAS No.

1420844-62-7

SMILES

O=C(C1=NC=C(F)C=C1)NCCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1044.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1790 mL 20.8951 mL 41.7903 mL
5 mM 0.8358 mL 4.1790 mL 8.3581 mL
10 mM 0.4179 mL 2.0895 mL 4.1790 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (26.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (26.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Melanin probe-1Melanin probe1Melanin probe 1OthersPETprobeimagingmalignantmelanomaB16F10tumor-bearingmiceInhibitorinhibitorinhibit

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Product name:
Melanin probe-1
Cat. No.:
HY-136404
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