MPS-Gαi2
MPS-Gαi2 is a membrane-permeable inhibitory peptide corresponding to the C-terminal sequence of Gαi2 involved in receptor interaction. MPS-Gαi2 blocks Hep I-induced binding of Gαi2 to LRP, thereby inhibiting pertussis toxin-sensitive Gαi2 signaling and focal adhesion disassembly mediated by thrombospondin/Hep I-calreticulin-LRP. MPS-Gαi2 can be used in studies on G protein signaling and cell adhesion regulation.
For research use only. We do not sell to patients.
- CAS No.: 1180485-56-6
- Formula: C119H203N29O30S
- Molecular Weight:2552.13
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MPS-Gαi2 (1 μM; 1 h incubation) specifically inhibits the binding of Gαi2 to LRP in bovine aortic endothelial cells stimulated by hep I, and abolishes the approximately 2.8-fold increase in binding levels induced by hep I treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1180485-56-6
-
Molecular Weight 2552.13
-
Formula C119H203N29O30S
-
Sequence
Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Lys-Asn-Asn-Leu-Lys-Asp-Cys-Gly-Leu-Phe
-
Sequence Shortening
AAVALLPAVLLALLAKNNLKDCGLF
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz