N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester

Name: N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester
Brand: MedChemExpress
SKU: HY-140581
Rating: 4.5 (0 reviews)

Cat. No.: HY-140581 Pureza: 95.0%: Ficha de datos
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N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester Estructura química

No. CAS : 2100306-76-9

Tamaño	Stock	Cantidad
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

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Based on 1 Customer Validation

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Descripciòn

N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

706.85

Fòrmula

C₃₀H₅₄N₆O₁₁S

No. CAS

2100306-76-9

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OC)CCOCCOCCOCCOCCN(C(CCCC[C@H]1SC[C@@]([C@@]1([H])N2)([H])NC2=O)=O)CCOCCOCCOCCN=[N+]=[N-]

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 95.0%

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Ficha de datos (264 KB) SDS (252 KB)

COA (243 KB) HNMR (135 KB) MS (133 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]