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Art. -Nr.: HY-N11989

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Nanangenine B

Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL.

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CAS. Nr.: 1609469-72-8
Formel: C₂₁H₃₂O₆
Molecular Weight:380.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Nanangenine B Chemical Structure

CAS. Nr.: 1609469-72-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC₅₀ of 38 μg/mL^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	49 μM Compound: 2	Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by IRSE-driven luciferase reporter assay Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by IRSE-driven luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	50.7 μM Compound: 2	Inhibition of Stat1 (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of Stat1 (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	55 μM Compound: 2	Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of TNF-alpha/IFN-gamma/IL-1beta-induced human CXCL10 (972 bp) promoter activity expressed in human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]
DLD-1	IC₅₀	68.4 μM Compound: 2	Inhibition of NF-kappaB (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay Inhibition of NF-kappaB (unknown origin)-induced human CXCL10 (972 bp) promoter activity expressed in TNF-alpha/IFN-gamma/IL-1beta-stimulated human DLD1 cells after 24 hrs by luciferase reporter assay	[PMID: 24792812]

Chemical Information

CAS. Nr. 1609469-72-8
Molecular Weight 380.48
Formel C₂₁H₃₂O₆
SMILES

C[C@]12[C@@](C(C)(CC[C@H]2O)C)([H])[C@@H](C=C3[C@@]1(C(OC3)=O)O)OC(CCCCC)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Microorganisms
Aspergillus
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lacey HJ, et al., Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019 Nov 5;15:2631-2643. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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