2. PROTAC
  3. PROTAC Linkers
  4. NH2-PEG1-C1-Boc

NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

NH2-PEG1-C1-Boc Chemical Structure

NH2-PEG1-C1-Boc Chemical Structure

CAS No. : 1155811-37-2

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NH2-PEG1-C1-Boc Related Antibodies

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Description

NH2-PEG1-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-PEG1-C1-Boc Related Antibodies
Molecular Weight

175.23

Formula

C8H17NO3
CAS No.
SMILES

O=C(OC(C)(C)C)COCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (142.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7068 mL 28.5339 mL 57.0679 mL
5 mM 1.1414 mL 5.7068 mL 11.4136 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7068 mL 28.5339 mL 57.0679 mL 142.6696 mL
5 mM 1.1414 mL 5.7068 mL 11.4136 mL 28.5339 mL
10 mM 0.5707 mL 2.8534 mL 5.7068 mL 14.2670 mL
15 mM 0.3805 mL 1.9023 mL 3.8045 mL 9.5113 mL
20 mM 0.2853 mL 1.4267 mL 2.8534 mL 7.1335 mL
25 mM 0.2283 mL 1.1414 mL 2.2827 mL 5.7068 mL
30 mM 0.1902 mL 0.9511 mL 1.9023 mL 4.7557 mL
40 mM 0.1427 mL 0.7133 mL 1.4267 mL 3.5667 mL
50 mM 0.1141 mL 0.5707 mL 1.1414 mL 2.8534 mL
60 mM 0.0951 mL 0.4756 mL 0.9511 mL 2.3778 mL
80 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7834 mL
100 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.4267 mL
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NH2-PEG1-C1-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-PEG1-C1-Boc1155811-37-2PROTAC LinkersInhibitorinhibitorinhibit

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