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Cat. No.: HY-N22058

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Nimonol

Name: Nimonol
Brand: MedChemExpress
SKU: HY-N22058
Availability: PreOrder

(Synonyms: Nimocinol)

Nimonol (Nimocinol) is a tetranortriterpenoid limonoid present in the leaves of Azadirachta indica, and it undergoes photolysis to generate Nimonolide. Nimonol interferes with insect growth processes, exerts antifeedant and insecticidal effects, and exhibits insecticidal toxicity against the fourth-instar larvae of Aedes aegypti. Nimonol is used in research related to pest control.

For research use only. We do not sell to patients.

CAS No.: 95260-96-1
Formula: C₂₈H₃₆O₅
Molecular Weight:452.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nimonol Chemical Structure

CAS No.: 95260-96-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

In Vitro

Nimonol exhibits no antifungal activity against Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus terreus, Candida albicans, or Microsporum gypseum^[2].
Nimonol undergoes photooxidation in benzene under UV light and oxygen, yielding Nimocinolide as the only detectable butenolide product^[3].
When Nimonol is exposed to UV light, it produces new photoproducts, among which photoproduct 4 Nimonolide exhibits antifeedant activity against Spodoptera litura^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Nimonol (Nimocinol) (41.40-82.80 ppm; in water; 24 h) exhibits larvicidal toxicity against fourth-instar Aedes aegypti larvae with an LC₅₀ of 83 ppm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aedes aegypti larvae (P.C.S.I.R. strain)^[1]
Dosage:

41.40, 51.75, 62.10, 72.45, 82.80 ppm
Administration:

in water; 24 h
Result:

Produced 8% mean mortality at 41.40 ppm.
Produced 14% mean mortality at 51.75 ppm.
Produced 28% mean mortality at 62.10 ppm.
Produced 44% mean mortality at 72.45 ppm.
Produced 54% mean mortality at 82.80 ppm.
Exhibited an LC5₀ of 83 ppm.

Chemical Information

CAS No. 95260-96-1
Molecular Weight 452.58
Formula C₂₈H₃₆O₅
SMILES

C[C@]12[C@@](CC[C@@]3(C2=CC[C@H]3C4=COC=C4)C)([H])[C@@]5([C@@](C(C)(C(C=C5)=O)C)([H])[C@H]([C@H]1OC(C)=O)O)C
Synonyms

Nimocinol
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Siddiqui BS, et al. Two insecticidal tetranortriterpenoids from Azadirachta indica. Phytochemistry. 2000 Feb;53(3):371-6.

[2]. Mahmoud DA, et al. Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2011 Jul;42(3):1007-16.

[3]. alimuzzaman Siddiqui, et al. Two new insect growth regulator meliacins from Azadirachta indica A. Juss (meliaceae). J. Chem. Soc., Perkin Trans. 1. 1986;15:1021-1025.

[4]. Geetha Gopalakrishnan, et al. Photooxygenation of Nimonol, a Tetranortriterpenoid from Azadirachta indica. A. Juss. Molecules. 2002;7(2):112-118.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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