2. Membrane Transporter/Ion Channel
  3. CFTR
  4. NJH-2-057

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

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NJH-2-057

NJH-2-057 화학구조

CAS No. : 2858812-70-9

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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NJH-2-057 Related Antibodies

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제품 설명

NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds ΔF508-CFTR.

분자량

810.84

화학식

C43H44F2N6O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CC(N(CC1)C2=CC=C(CCC(NCCCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)O2)=O)C=C
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (123.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2333 mL 6.1664 mL 12.3329 mL
5 mM 0.2467 mL 1.2333 mL 2.4666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2333 mL 6.1664 mL 12.3329 mL 30.8322 mL
5 mM 0.2467 mL 1.2333 mL 2.4666 mL 6.1664 mL
10 mM 0.1233 mL 0.6166 mL 1.2333 mL 3.0832 mL
15 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0555 mL
20 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5416 mL
25 mM 0.0493 mL 0.2467 mL 0.4933 mL 1.2333 mL
30 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0277 mL
40 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
50 mM 0.0247 mL 0.1233 mL 0.2467 mL 0.6166 mL
60 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5139 mL
80 mM 0.0154 mL 0.0771 mL 0.1542 mL 0.3854 mL
100 mM 0.0123 mL 0.0617 mL 0.1233 mL 0.3083 mL
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NJH-2-057 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJH-2-0572858812-70-9CFTRCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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Inquiry Information

상품명:
NJH-2-057
Cat. No.:
HY-115878
수량:
MCE Japan Authorized Agent:

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