NLRP3-IN-44
NLRP3-IN-44 (compound P33) is a potent and orally active (approximately 62%) inhibitor of NLRP3, with the Kd of 17.5 nM. NLRP3-IN-44 plays an important for studying NLRP3 inflammasome-mediated diseases.
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- CAS No.: 3040298-34-5
- Formule: C25H30N4O3
- Masse moléculaire:434.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
0.003 μM
Compound: P33
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Inhibition of IL-1beta release in PMA-differentiated/ LPS and nigericin stimulated human THP-1 cells pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins and later stimulated with nigericin for 40 mins by ELISA
Inhibition of IL-1beta release in PMA-differentiated/ LPS and nigericin stimulated human THP-1 cells pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins and later stimulated with nigericin for 40 mins by ELISA
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[PMID: 39169676] |
Chemical Information
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CAS No. 3040298-34-5
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Masse moléculaire 434.53
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Formule C25H30N4O3
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SMILES
OC1=C(C(N=NC(N[C@H]2CN(CCC2)CCO)=C34)=C3C5CCC4CC5)C=CC6=C1C=CO6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-44 Related Classifications
HY-162846 Related Classifications
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