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Cat. No.: HY-168520

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NLRP3-IN-57

NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing IL-1β levels in LPS plus Nigericin-induced THP-1 macrophages..

For research use only. We do not sell to patients.

Formula: C₄₄H₆₀O₇
Molecular Weight:700.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NLRP3-IN-57 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing IL-1β levels in LPS plus Nigericin-induced THP-1 macrophages.^[1].

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

Molecular Weight 700.94
Formula C₄₄H₆₀O₇
SMILES

COC(C)(/C=C/C/C(C)=C/C[C@@H]1C[C@]2(C(C(C(C3=CC(O)=C(C=C3)O)=O)=C([C@](C2=O)([C@]1(CC/C=C(C)/C)C)C/C=C(C)\C)O)=O)C/C=C(C)\C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu XY, et al. Anti-inflammatory bicyclic polyprenylated acylphloroglucinols with diverse architectures including an unprecedented 6/6/6 tricyclic core from Garcinia yunnanensis. Bioorg Chem. 2024 Dec;153:107864. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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References

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NLRP3-IN-57

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NLRP3-IN-57 Related Classifications

HY-168520 Related Classifications

Bioz

Keywords

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