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Cat. No.: HY-N3765

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Diosbulbin D

Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells.

For research use only. We do not sell to patients.

CAS No.: 66756-57-8
Formula: C₁₉H₂₀O₆
Molecular Weight:344.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Diosbulbin D Chemical Structure

CAS No.: 66756-57-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells^[1].

In Vitro

Diosbulbin D (10-80 μM; 12-72 h) can induce cytotoxicity in human normal liver L-02 cells^[1].
Diosbulbin D (40 μM; 24 h) induces morphological changes in L-02 cells^[1].
Diosbulbin D (20-80 μM; 12-48 h) induces L-02 cells apoptosis in a time- and concentration-dependent manner^[1].
Diosbulbin D (20-80 μM; 24 h) induces activation of caspase 3 in L-02 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L-02 cells
Concentration:

10, 20, 40 and 80 μM
Incubation Time:

12, 24, 48 and 72 h
Result:

Decreased L-02 cells viability in a concentration- and time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

L-02 cells
Concentration:

20, 40 and 80 μM
Incubation Time:

12, 24 and 48 h
Result:

Induced apoptosis in a time- and concentration-dependent manner.

Chemical Information

CAS No. 66756-57-8
Molecular Weight 344.36
Formula C₁₉H₂₀O₆
SMILES

CC12C3C(C(CC1C(OC(C4=COC=C4)C2)=O)=O)C5CC(OC5=O)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma M, et al. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells. Exp Toxicol Pathol. 2012 Sep;64(6):611-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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