FINO2
Based on 14 publication(s) in Google Scholar
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 869298-31-7
- Formula: C15H28O3
- Molecular Weight:256.38
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) FINO2
More- Nature. 2026 Jul;655(8121):240-250. [Abstract]
- Autophagy. 2026 Feb 15:1-19. [Abstract]
- Nat Commun. 2025 Mar 26;16(1):2951. [Abstract]
- J Nanobiotechnology. 2026 Feb 12;24(1):158. [Abstract]
- J Exp Clin Cancer Res. 2024 May 3;43(1):133. [Abstract]
- Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
- Cell Rep Med. 2025 Sep 25:102371. [Abstract]
- Cell Death Differ. 2026 May 26. [Abstract]
- J Immunother Cancer. 2024 Nov 24;12(11):e009805. [Abstract]
- Dev Cell. 2024 Feb 26;59(4):517-528.e3. [Abstract]
- Anal Chem. 2025 Nov 18;97(45):25056-25066. [Abstract]
- Microchem J. 2025 Sep 9;218:115245.
- Microchem J. 2024 Dec.
- SSRN. 2025 Dec 2.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
Biological Activity
FINO2 (10 μM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 869298-31-7
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Appearance Solid
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Molecular Weight 256.38
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Formula C15H28O3
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Color White to off-white
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SMILES
OCCC1(C[C@](CC[C@H]2C(C)(C)C)(CC2)OO1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (14)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jul;655(8121):240-250. PMID: 42236947 -
Autophagy
Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 axis. [Abstract]2026 Feb 15:1-19. PMID: 41612599 -
Nat Commun
2025 Mar 26;16(1):2951. PMID: 40140422 -
J Nanobiotechnology
A dual-action nanoparticle approach for spinal cord injury treatment: ferroptosis inhibition, inflammation control, and Myelin preservation. [Abstract]2026 Feb 12;24(1):158. PMID: 41673859 -
J Exp Clin Cancer Res
Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis. [Abstract]2024 May 3;43(1):133. PMID: 38698462
FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133. [Abstract]
Viability of FCN3- and nsFCN3-overexpressed MHCC97-H cells treated with indicated concentrations of FINO2 (0-6 μM) for 24 h.
FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133. [Abstract]
Representative images of nsFCN3-overexpressed YY-8103 cells treated with FINO2 (10 µM) and Ferr-1 (2 µM). Scale bar, 100 μm.
FINO2 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 May 3;43(1):133. [Abstract]
Representative images of nsFCN3-overexpressed YY-8103 cells treated with FINO2 (10 µM) and NAC (1 mM). Scale bar, 100 μm.
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Adv Sci (Weinh)
2025 Jan 31:e2408845. PMID: 39888307
FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
Lipid peroxidation of FSP1‐depleted HCT116 cells treated with FINO2 (20 µM) for 12 h.
FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
HCT116 cells death of HCT116 cells treated with SAHA and FINO2 (20 µm) for 24 h.
FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
Cell death (detected at 24 h) of HCT116 cells treated with different FINs (RSL3: 5 µM, erastin: 40 µM, FINO2: 20 µM).
FINO2 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845. [Abstract]
lipid peroxidation (detected at 12 h) of HCT116 cells treated with different FINs (RSL3: 5 µM, erastin: 40 µM, FINO2: 20 µM).
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Cell Rep Med
Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis. [Abstract]2025 Sep 25:102371. PMID: 41005298 -
Cell Death Differ
Fatty acid channelling into triglycerides and oxylipins drives ferroptosis resistance during oncogenic BRAF-induced senescence. [Abstract]2026 May 26. PMID: 42191968 -
J Immunother Cancer
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. [Abstract]2024 Nov 24;12(11):e009805. PMID: 39581704 -
Dev Cell
A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis. [Abstract]2024 Feb 26;59(4):517-528.e3. PMID: 38272028 -
Anal Chem
Ferroptosis Pathway Discrimination and Anticancer Therapeutic Screening Enabled by Cascade-Activated Fluorescence Reporting of Cysteine-Viscosity Dynamics. [Abstract]2025 Nov 18;97(45):25056-25066. PMID: 41191406 -
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Solvent & Solubility
DMSO : 50 mg/mL (195.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9005 mL | 19.5023 mL | 39.0046 mL | 97.5115 mL |
| 5 mM | 0.7801 mL | 3.9005 mL | 7.8009 mL | 19.5023 mL | |
| 10 mM | 0.3900 mL | 1.9502 mL | 3.9005 mL | 9.7512 mL | |
| 15 mM | 0.2600 mL | 1.3002 mL | 2.6003 mL | 6.5008 mL | |
| 20 mM | 0.1950 mL | 0.9751 mL | 1.9502 mL | 4.8756 mL | |
| 25 mM | 0.1560 mL | 0.7801 mL | 1.5602 mL | 3.9005 mL | |
| 30 mM | 0.1300 mL | 0.6501 mL | 1.3002 mL | 3.2504 mL | |
| 40 mM | 0.0975 mL | 0.4876 mL | 0.9751 mL | 2.4378 mL | |
| 50 mM | 0.0780 mL | 0.3900 mL | 0.7801 mL | 1.9502 mL | |
| 60 mM | 0.0650 mL | 0.3250 mL | 0.6501 mL | 1.6252 mL | |
| 80 mM | 0.0488 mL | 0.2438 mL | 0.4876 mL | 1.2189 mL | |
| 100 mM | 0.0390 mL | 0.1950 mL | 0.3900 mL | 0.9751 mL |
FINO2 Related Classifications
HY-129457 Related Classifications
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