Oleyl anilide
Based on 1 Customer Validation
Oleyl anilide (Oleic acid anilide) is a toxic agent found in some stocks of toxic oil, which is associated with toxic oil syndrome (TOS). Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT) (IC50: 26 µM).
For research use only. We do not sell to patients.
- Purity : 95.2%
- CAS No.: 5429-85-6
- Formula: C24H39NO
- Molecular Weight:357.57
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BTI-TN-5B1-4 | IC50 |
0.14 μM
Compound: oleic acid anilide
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Inhibition of human ACAT1 expressed in Hi5 cells
Inhibition of human ACAT1 expressed in Hi5 cells
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[PMID: 16919944] |
| BTI-TN-5B1-4 | IC50 |
0.17 μM
Compound: oleic acid anilide
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Inhibition of human ACAT2 expressed in Hi5 cells
Inhibition of human ACAT2 expressed in Hi5 cells
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[PMID: 16919944] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female MRL+/+ mice[2]
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Dosage:0.8 mmol/kg
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Administration:i.p., twice a week for 6 weeks
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Result:Increaseed IgG, IgG1, IgG2a, IgG3, IgE and IgG2b levels.
Increased lymphocyte population.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 5429-85-6
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Appearance Solid
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Molecular Weight 357.57
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Formula C24H39NO
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Color White to yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC(NC1=CC=CC=C1)=O
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Synonyms
Oleic acid anilide; OAA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Roth BD, et al. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem. 1992 May 1;35(9):1609-17. [Content Brief]
[2]. Cai P, et al. Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice. J Immunotoxicol. 2005 Oct 1;2(4):231-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oleyl anilide Related Classifications
HY-114619 Related Classifications
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