Otenabant Hydrochloride
Based on 3 publication(s) in Google Scholar
Otenabant Hydrochloride is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
For research use only. We do not sell to patients.
- Purity : 99.47%
- CAS No.: 686347-12-6
- Formula: C25H26Cl3N7O
- Molecular Weight:546.88
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Otenabant Hydrochloride
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Biological Activity
Description
IC50 & Target
Ki: 0.7 nM (CB1)
In Vitro
Otenabant HCl has low affinity with Ki of 7.6 μM for human CB2 receptors[1]. Otenabant HCl inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 686347-12-6
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Appearance Solid
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Molecular Weight 546.88
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Formula C25H26Cl3N7O
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Color White to off-white
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SMILES
[H]Cl.ClC1=CC=CC=C1C2=NC3=C(N4CCC(NCC)(C(N)=O)CC4)N=CN=C3N2C5=CC=C(Cl)C=C5
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Synonyms
CP 945598 Hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Sci China Life Sci
2022 Feb;65(2):341-361. PMID: 34047913 -
Int J Mol Sci
2024 May 3;25(9):5012. PMID: 38732230 -
Biomedicines
Adipose Stem Cell-Derived Apoptotic Vesicles Attenuate Hypertrophic Scarring by Targeting the CDC20/WNT Signaling Pathway. [Abstract]2026 May 11;14(5):1083. PMID: 42193410
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (91.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8286 mL | 9.1428 mL | 18.2855 mL | 45.7139 mL |
| 5 mM | 0.3657 mL | 1.8286 mL | 3.6571 mL | 9.1428 mL | |
| 10 mM | 0.1829 mL | 0.9143 mL | 1.8286 mL | 4.5714 mL | |
| 15 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0476 mL | |
| 20 mM | 0.0914 mL | 0.4571 mL | 0.9143 mL | 2.2857 mL | |
| 25 mM | 0.0731 mL | 0.3657 mL | 0.7314 mL | 1.8286 mL | |
| 30 mM | 0.0610 mL | 0.3048 mL | 0.6095 mL | 1.5238 mL | |
| 40 mM | 0.0457 mL | 0.2286 mL | 0.4571 mL | 1.1428 mL | |
| 50 mM | 0.0366 mL | 0.1829 mL | 0.3657 mL | 0.9143 mL | |
| 60 mM | 0.0305 mL | 0.1524 mL | 0.3048 mL | 0.7619 mL | |
| 80 mM | 0.0229 mL | 0.1143 mL | 0.2286 mL | 0.5714 mL |
Otenabant Hydrochloride Related Classifications
HY-10871A Related Classifications
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