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Cat. No.: HY-168474

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P2X4 antagonist-4

P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC₅₀ value of 8 µM. P2X4 antagonist-4 blocks the ATP-induced NLRP3 inflammasome activation and release of IL-1β.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₂FN₃O₄S
Molecular Weight:503.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

P2X4 antagonist-4 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC₅₀ value of 8 µM. P2X4 antagonist-4 blocks the ATP-induced NLRP3 inflammasome activation and release of IL-1β^[1].

IC₅₀ & Target^[1]

P2X4 Receptor

8 μM (IC₅₀)

All P2X Receptor Isoforms :

Chemical Information

Molecular Weight 503.54
Formula C₂₇H₂₂FN₃O₄S
SMILES

O=S(CC1=CC=C(F)C=C1C)(NC2=CC=C(N(C(C3)=O)C4=CC=C5C=CC=CC5=C4NC3=O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Erlitz KS, et al. Naphtho[1,2-b][1,4]diazepinedione-Based P2X4 Receptor Antagonists from Structure-Activity Relationship Studies toward PET Tracer Development. J Med Chem. 2025 Jan 13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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P2X4 antagonist-4

All P2X Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

P2X4 antagonist-4 Related Classifications

HY-168474 Related Classifications