P2Y14R antagonist 2
Based on 1 Customer Validation
P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40 nM. P2Y14R antagonist 2 shows anti-inflammatory activity. P2Y14R antagonist 2 has the potential for the research of colitis.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 2989271-65-8
- Formula: C18H13FN2O4S
- Molecular Weight:372.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
All P2Y Receptor Isoforms
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Biological Activity
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P2Y14 Receptor 0.40 nM (IC50) |
Pharmacokinetic Parameters[1].
| Parameters | dose (mg/kg) | Cmax (ng/mL) | T1/2 (min) | Tmax (min) | AUCall (min*ng/mL) | CL (mL/min/kg) | F (%) |
| iv | 1.0 | - | 21 ± 8.4 | - | 27924 ± 5520 | 133.8 ± 33 | - |
| po | 5.0 | 518.25 ± 196.26 | 177.6 ± 24.6 | 15 | 90744 ± 21613 | 232.2 ± 46.2 | 65.0 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, 20-22 g, male C57BL/6 mice (colitis) [1]
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Dosage:50, 100 µM for 100µL per mice
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Administration:Rectally administered, daily for 7 days
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Result:Alleviated DSS-induced body weight loss, loose stools, rectal bleeding, colon shortening, and elevated spleen weighted index.
Chemical Information
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CAS No. 2989271-65-8
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Appearance Solid
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Molecular Weight 372.37
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Formula C18H13FN2O4S
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Color White to off-white
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SMILES
O=C(C1=CC(NC(C2=CC=C(C=C2)C)=O)=C(S1)OC3=NC=C(C=C3)F)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)